Text S1 Energy landscape reveals that the budding yeast cell cycle is a robust and adaptive multi-stage process Supporting Information
نویسندگان
چکیده
I. The three-node Budding Yeast Cell Cycle Model II. Stochastic Model III. Large Deviation Theory and the Hamiltonian IV. Overview of the Construction of the Landscape V. Introduction of the gMAM V-A. The Outer Loop V-B. Evaluating the Action V-C. The Inner Loop VI. Construction of the Quasi-potential energy landscape VI-A. Landscape with One Stable State VI-B. Landscape with Two Stable States VI-C. Landscape with one stable limit cycle VI-D. Pseudo Landscape with the Non-gradient Force VI-E. Projecting the 3-D Landscape onto 2-D Plane VII. Force Strength and Landscape Canal width VIII. Analysis of the Non-gradient Force IX. Signals Regulation in the Cell Cycle model X. Extrinsic and Intrinsic Noise XI. Parameters Sensitivity Analysis
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